Multicenter outcome study of cancer patients admitted to the intensive care unit: a probability of mortality model.

PURPOSETo develop prospectively and validate a model for probability of hospital survival at admission to the intensive care unit (ICU) of patients with malignancy.PATIENTS AND METHODSThis was an inception cohort study in the setting of four ICUs of academic medical centers in the United States. Defined continuous and categorical variables were collected on consecutive patients with cancer admitted to the ICU. A preliminary model was developed from 1,483 patients and then validated on an additional 230 patients. Multiple logistic regression modeling was used to develop the models and subsequently evaluated by goodness-of-fit and receiver operating characteristic (ROC) analysis. The main outcome measure was hospital survival after ICU admission.RESULTSThe observed hospital mortality rate was 42%. Continuous variables used in the ICU admission model are PaO2/FiO2 ratio, platelet count, respiratory rate, systolic blood pressure, and days of hospitalization pre-ICU. Categorical entries include presence of int...