Genomic Variations of SARS-COV-2 and Detection/ 新型冠状病毒基因组变异与诊断

Rapid and accurate detection of contagium virus is a key tool for controlling the outbreak As the number of patients infected with 2019 novel coronavirus (2019-nCoV or SARS-CoV-2) pneumonia is increasing and the epidemic is spreading, many hospitals, laboratories and pharmaceutical companies have developed diagnostic reagents that can detect SARS-CoV-2 Currently, genome sequencing or real-time PCR is the approach to detect SARS-CoV-2 However, there have been reported the clinical patients with pneumonia of negative results by SARS-CoV-2 nucleic acid detection but positive on the radiological CT scan It brings new challenges to the clinical practitioners since it is unclear for the specificity of CT to diagnose the 2019-nCoV pneumonia (NCP) Therefore, how to improve the diagnostic efficiency and the sensitivity of molecular detection remains to be solved To analyze the variations in viral genomic sequence may be helpful in guiding the prevention and treatment of diseases infected by SARS-CoV-2 At present, controversy still exists over the source of SARS-CoV-2 even though the probable origin is bat in nature This article summarizes the recent findings of SARS-CoV-2 from genetic, virological and evolutionary biological perspectives By comparing the genomic variations among SARS-CoV-2 infected patients, we hope the findings can be used in the viral detection and potential antiviral therapy Also, it will be great if we can trace the spread of the virus from one person to another, which will be a much effective way to predict and control the spread from the virus-carrier without symptoms at the incubation period to the others