Targeting adipose tissue angiogenesis to enhance insulin sensitivity

Adipose tissue plays an essential role in metabolic homeostasis. Abnormal expansion of (obesity) and markedly reduced (lipodystrophy) adipose tissue mass represent the extreme opposite ends of the adiposity spectrum. Intriguingly, both lead to metabolic dysfunction including insulin resistance and type 2 diabetes. Furthermore, adipose tissue is today recognised as an important endocrine organ and dysregulated secretion of adipokines may lead to profound changes in insulin sensitivity.