Substituted 3,4-dihydro-pyrido [2,3-b] pyrazin-2 (1H) -one

The present invention relates BET proteininhibitorische, particularly BRD4 inhibitory substituted Substituted 3,4-dihydropyrido [2,3-b] pyrazin-2 (1H) -ones of the general formula I in which R Furthermore, this invention relates to the use of BET protein inhibitors in viral infections, in neurodegenerative diseases, in inflammatory diseases, in atherosclerotic disease and in male fertility control.