Palladium(0)-Catalyzed Alkylarylation of N-Alkyl-N-methacryloylbenzamides with Alkyl Iodides

An efficient Pd(0)-catalyzed alkylarylation of N -alkyl- N -methacryloylbenzamides with alkyl iodides for the synthesis of isoquinoline-1,3-diones is described. A highlight of the method is its excellent functional-group tolerance. Mechanistic investigations suggest that a radical addition/cyclization process is probably involved in the sequences.