Vergleich der in vivo-Zelladhäsion verschiedener Kolonkarzinomzellen

Tumor cell adhesion within the microcirculation of host organs is a fundamental event in the formation of distant tumor metastases. Circulating tumor cells have to adhere within the microcirculatory vessels, quickly stabilize their adhesion and probably leave the circulation to avoid toxic effects of hydrodynamic shear forces of circulating blood. However, in vivo controversial results have been reported for the complex interactions between circulating tumor cells and host organs in different experimental models.