Stress-induced Arterial Hypertension At A Working Place: Particularities Of Cardiovascular Fitness: Pp.25.19

115 subjects were included in this study. The main group (n = 46) were the ones whose differences in daily average systolic (SBP) and diastolic blood pressure (DBP) obtained on working day and on weekend during the BP daily monitoring were 6 and/or 3 and more mm of mercury. The control set (n = 69) were the normotensives according to BP daily monitoring. Groups were comparable on a sex, age and the work experience. Ambulatory blood pressure monitoring, echocardiography, pulse ware velocity, morning cortisol level, magnesium level and microalbuminuriawere measured in all patients included in study. Persons with stress-induced hypertension at a working place (SIH) showed significantly higher 24-hour SBP load (46 ± 2,73) % and DBP (49,8 ± 2,38) % in a working day as compared with (28,9 ± 2,21) % for SBP load and (30,2 ± 2,53) % for DBP load in rest day (p < 0,05). The rate of person with increased pulse pressure among the patient with SIH (24%) was significantly higher than among the normotensives (4 %) (χ2 = 5,73, ð = 0,017) as well as the rate of persons with nocturnal hypertension («night-peaker») in a working day in comparison with a day off. Patients with SIH had elevated cortisol (959,4 54,5 nmol/l) and lowered magnesium (0,79 0,016 mmol/l) level. SIH leads to the subclinical end organ damage: left ventricular mass (233,6 ± 8,83) and relative wall thickness (0,40 ± 0,008) increase, all these indices were significantly higher in patient with SIH than in normotensives. Increase of left atrium diameter was revealed in 30% of patient with SIH, grade I of diastolic dysfunction – in 26%, microalbuminuria - in 12%, puls weve velosyty augmentation – in 31%. Persons with SIH are characterised by an adverse daily profile the BP, presence of subclinical end-organs damage and changes of biochemical markers of stress.