Assessment of Some Serum Markers of Kidneys in Rabbits Treated By Mitracarpus Scaber (Rubiaceae)

The aim of the present study was to investigate the renal tolerance of Mitracarpus scaber (Rubiaceae) in rabbits. It is a plant traditionally used to treat skin diseases and various ailments in Cote d'Ivoire and elsewhere in West Africa. For this study, different batches of rabbits were injected with increasing doses of aqueous extract of Mitracarpus scaber (encoded Misca). Then changes in serum urea, creatinine and uric acid were evaluated. This study showed that the use of the aqueous extract of Mitracarpus scaber with doses between 12.5 and 200 mg / kg body weight (bw) in rabbits causes a significant variation (P 0.05) of urea serum concentration. Finally, this study suggests that a reduction of the dose (100 mg / kg) and time of treatment (4 weeks) may help to avoid kidney dysfunction other time. This dose of 100 mg / kg/bw which is much higher than the therapeutic dose, confer on Mitracarpus scaber a safety margin 530 (Tolerate Maximum Dose/ Therapeutic dose) very interesting.