P268 CHRONIC INTERMITTENT HYPOXIA EXACERBATES ENDOTHELIAL DYSFUNCTION IN NON-ALCOHOLIC FATTY LIVER DISEASE

Results: Mice in each experimental group showed PE-like phenomenon. Placental and fetal weights were significantly lower in PE-like groups compared to corresponding control group (P < 0.05). Concentrations of FFA and TG were significantly increased in PE-like groups compared to corresponding control group (P < 0.05), except in models induced by LPS. Conclusions: A variation of FFA and TG among PE-like model types suggests that fatty acid oxidation disorders exist to some extent and may be shared through different pathways in multifactorial pathogenesis in PE. Supported by Grant NNSF of China No. 81370723 and Beijing MNSF No. 71372215.