Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives as antibacterial and antifungal agents

Abstract A series of new pyrrole derivatives, pyrrolo[2,3- d ]pyrimidine derivatives, pyrrolotriazolopyrimidines and pyrrolotetrazolopyrimidines were synthesized. The evaluation of their antimicrobial activities against Staphylococcus aureus , Escherichia coli , and Candida albicans were carried out. Pyrrolo[2,3- d ]pyrimidines 3a–d , 7a , e , 11d exhibited excellent activity against C. albicans with MIC 0.31–0.62 mg/mL. These compounds displayed better antifungal activity than that of standard drug (fluconazole with MIC 1.5 mg/mL). Furthermore, pyrrolo[2,3- d ]pyrimidines 3b,c , 7e exhibited the best activity against S. aureus with MIC 0.31 mg/mL, compared with the standard drug (ampicillin with MIC 0.62 mg/mL). The rest of the compounds were found to be inactive against bacteria and fungi.