CORRELATION OF KI-67 WITH PROGNOSTIC HORMONE RECEPTOR MARKERS IN BREAST CARCINOMA

Ki67 is a proliferative marker which has therapeutic, predictive and prognostic value in breast carcinoma. The aim of the study was to analyse the correlation of Ki-67 labeling index with other prognostic markers like ER, PR, and HER2. This was a hospital based cross sectional comparative analysis conducted in Department of Pathology, Amala institute of Medical Sciences, Kerala, India during a period of 18 months, from January 2015 to June 2016. In total, 230 specimens of lumpectomy, mastectomy and trucut biopsies from primary breast cancer patients were enrolled in the study.  The immunohistochemical staining for Ki 67,Estrogen Receptor(ER), Progesterone Receptor(PR), and Human Epidermal growth factor Receptor 2(HER2) were done and scored according to specific criteria. The association between Ki 67 scores and others were evaluated.