Significance of HLA-DR expression in serous epithelial ovarian carcinoma combined with serum CA125 in evaluating ovarian carcinoma malignancy behavior

AIM:To evaluate the malignancy behavior of serous epithelial ovarian carcinoma with HLA-DR expression and serum CA125.METHODS:Forty cases of serous ovarian carcinoma,twelve cases of serous ovarian cystadenoma and ten cases of normal ovarian tissues were collected,and the level of pre-operational serum CA125 in ovarian carcinoma patients was also collected.HLA-DR was detected with immunohistochemistry in all cases.RESULTS:The positive rate of HLA-DR was 50.0% in serous ovarian carcinoma tissues,obviously higher than that in both benign epithelial ovarian tumor and normal ovarian tissues.Significant difference was found in the positive rate of HLA-DR between early and late stages.The positive rate of HLA-DR was obviously higher in high differentiated group than that in medium and low differentiated group.HLA-DR expression had negative correlation with the pre-operational serum CA125 level.CONCLUSION:The expression of HLA-DR and high level of pre-operation serum CA125 can be markers to evaluate ovarian carcinoma malignancy behavior.