Photodynamic therapy of brain tumours: effect in culture of glioma (stamm 101.8)

The effect of photodynamic action on glial tumour of brain has been investigated in cell culture of experimental glioma rat brain (stamm 101.8), which aproximate in histobiological characteristics to human malignant glioma of brain. We used photosensitizer sulphonated aluminium phthalocyanine in experiments. It was determined that incubation of tumour cells in substratum with photosensitizer alone during 24—48 hours was not elicit any important changes in structure of growth zone in culture. In cultures of glioma with photosensitizer and laser irradiation was showed a dose-depended effect of tumour cell destruction. Results of our study have pointed on positive effect of usage the second generation photosensitizer sulphonated aluminium phthalocyanine for photodynamic therapy of malignant gliomas of brain.