NAMPT enzyme activity regulates catabolic gene expression in gingival fibroblasts during periodontitis

The over-expression of an enzyme and its knock-on effects on gene regulation play a key role in gum disease and may inform future treatments. Chronic inflammation of the gums and the associated destruction of tissues and bone structures is a major health problem worldwide. Je-Hwang Ryu at Chonnam National University and scientists across the Republic of Korea investigated a known pro-inflammatory enzyme called nicotinamide phosphoribosyltransferase (NAMPT) to determine its role in gum disease. They found that localized expression of NAMPT was dramatically increased in inflamed mouse and human gum tissues. The over-expression of NAMPT affected the expression of genes involved in catabolic pathways, as well as triggering the destruction of the bone that holds teeth in place. NAMPT could be a potential target in future treatment of gum disease.