Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3

William C. Groutas,Michael J. Brubaker,Lee S. Chong,Radhika Venkataraman,He Huang,Jeffrey B. Epp,Rongze Kuang,John R. Hoidal

Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3

1995

William C. Groutas
Michael J. Brubaker
Lee S. Chong
Radhika Venkataraman
He Huang
Jeffrey B. Epp
Rongze Kuang
John R. Hoidal

Abstract A structure-activity relationship study and in vitro biochemical studies with human leukocyte elastase, cathepsin G and proteinase 3 were conducted using a series of succinimide derivatives.

Keywords:

Cathepsin O
Cathepsin L1
Proteinase 3
Cathepsin A
Human Leukocyte Elastase
Biochemistry
Structure–activity relationship
In vitro
Cathepsin G
Chemistry
Succinimide derivatives

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