Highly Efficient One-Pot Synthesis of N-Acylsulfonamides Using Cyanuric Chloride at Room Temperature

A highly efficient and very mild one-pot synthesis of N- acylsulfonamides is described using cyanuric chloride. In this syn- thesis, structurally diverse carboxylic acids and sulfonamides are reacted in the presence of cyanuric chloride, triethylamine, and alu- mina in anhydrous acetonitrile at room temperature to afford vari- ous N-acylsulfonamides in excellent yields.