Predictive role of tear protein expression in the early diagnosis of Sjögren’s syndrome:

BackgroundThe contribution of tear protein expression in patients with presumed diagnosis of Sjogren syndrome is underestimated. We aimed to evaluate the role of tear proteins in the Sjogren syndrome early diagnosis.MethodsCharts from 110 patients suspected of Sjogren syndrome were analysed and the subsequent diagnosis retrieved. Subjective symptoms (ocular surface disease index, OSDI), tear film break-up time (TFBUT), Schirmer test, Jones test, tear clearance (TC), corneal (NEI score) and conjunctival staining (van Bjerstelveldt score), esthesiometry, cytology, tear protein analysis (total protein [TP] content, lysozyme-C [LYS-C], lactoferrin [LACTO], lipocalin-1 [LIPOC-1] and albumin [ALB]) were analysed. The diagnostic performance with area under the curve (AUC) and odds ratio (OR) for each parameter were calculated.ResultsThirty-five patients (31.8%) had been diagnosed as affected by Sjogren syndrome. Clinical tests showed lower diagnostic performance (OSDI > 44 [AUC 0.57], Schirmer ≤ 5 mm [0.59], TFB...