Differential expression of peroxisome proliferator-activated receptors (PPARs) in the developing human fetal digestive tract.

SUMMARY We investigated the spatiotemporal distributions of the different peroxisome proliferator-activated receptor (PPAR) isotypes ( � , � , and � ) during development (Week 7 to Week 22 of gestation) of the human fetal digestive tract by immunohistochemistry using specific polyclonal antibodies. The PPAR subtypes, including PPAR � , are expressed as early as 7 weeks of development in cell types of endodermal and mesodermal origin. The pres