The establishment of testicular fibrosis model in Wistar rats

OBJECTIVES: To establish the testicular fibrosis model in rats. METHODS: Wistar rats were divided into control group(n = 12) and model group(n = 40) randomly. Testicular fibrosis model was built with the classical method of establishing experimental autoimmune orchitis (EAO) combined with injecting Bacille Calmette-Guerin (BCG) into left testis. RESULTS: The incidence rate of EAO and the rate of testicular fibrosis were 100%, 11.1% and 100%, 81.5% at 80, 140 days after the first infection, respectively. CONCLUSIONS: The model of rat testicular fibrosis was established successfully.