Highly selective and reproducible electroanalysis for histidine in blood with turn-on responses at a potential approaching zero using tetrahedral copper metal organic frameworks

A highly selective and reproducible electroanalysis strategy was developed for probing histidine using tetrahedral copper metal organic frameworks. It can facilitate His detection through the stable “turn-on” signal output of solid-state CuCl electrochemistry at a potential approaching zero, with the level down to about 25 nM in blood.