Natural Products Derived from Naphthalenoid Precursors by Oxidative Dimerization

In the last decade, a structurally diverse class of new bioactive natural products was isolated from fungi in which two naphthalene units are fused together via oxidative coupling. These compounds attracted attention because of their antifungal, antibacterial, and antitumoral activity. In addition, several enzymes, namely: phospholipase D, DNA gyrase, and Ras farnesyl-protein transferase, were also found to be inhibited with high selectivity.