A role for guanidino compounds in the brain

Guanidino compounds of guanidinoethanesulfonic acid, guanidinoacetic acid, guanidinosuccinic acid, N-acetylarginine, β-guanidinopropionic acid, creatinine, γ-guanidinobutyric acid, arginine, guanidine, methylguanidine, homoarginine and α-guanidinoglutaric acid are present in the mammalian brain. These guanidino compounds except for arginine and guanidine induce seizures and convulsions in rat, rabbit and cat by intracisternal injection.