Synthesis and Antibacterial Activity of 1β‐Methylcarbapenem Having a 1,3‐Diazabicyclo[3.3.0]octan‐4‐one Moiety, Part II
1999
The synthesis of a new series of 1β-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octan-4-one moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria are tested and the effect of substituent on the bicyclic ring was investigated. A particular compound (11h) having aminoethyl group showed the most potent antibacterial activity.
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