A HIGHLY STABLE WATER-INSOLUBLE DERIVATIVE OF RIBONUCLEASE T1

A water-insoluble derivative of ribonuclease T1 (RNase T1) was prepared by chemically combining RNase T1 with a copolymer of acrylamide and divinylbenzene (Enzacryl AH), and its enzymatic properties were examined. The enzyme derivative retained much of its original activity and was considerably more stable to heat and extremes of pH than the native enzyme.