Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
2015
Introduction
Microglia are tissue macrophages of the central nervous system that monitor brain homeostasis and react upon neuronal damage and stress. Aging and neurodegeneration induce a hypersensitive, pro-inflammatory phenotype, referred to as primed microglia. To determine the gene expression signature of priming, the transcriptomes of microglia in aging, Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS) mouse models were compared using Weighted Gene Co-expression Network Analysis (WGCNA).
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
62
References
329
Citations
NaN
KQI