Respiratory syncytial virus infection enhances airway hyperresponsiveness in guinea pigs and the underlined mechanism

Aim:To study the relation between Respiratory Syncytial Virus infection and asthma development by measuring airway responsiveness (AR)and M2R function.Methods:Guinea pigs(n=34)were randomly divided into 4 groups:Hep-2/NS group(group A,n=9),RSV/NS group(group B,n=9),Hep-2/OVA group(group C,n=8)and RSV/OVA group(group D,n=8).On day 21 after infection we tested AR and M2R.Then counted eosinophils in BALF and observed pathological change.Results:Intraairway pressure(IP mmH_2 O)of group B had no significant difference with group A(P0.01),and the extent of IP decrease also had no difference between groups A and B(P0. 05),but IP of C group were much higher than group A(P0.05),with extent of IP decrease lower than group A(P0.05).And IP of group D were higher than group C(P0.01),with the extent of IP decrease much lower than group C(P0.05).Conclusion:RSV infection could enhance OVA-induced M2R dysfunction,then develop AHR.