Association of Hippo Signalling Pathway with Epigenetic Changes in Cancer Cells and Therapeutic Approaches: An Update Review.

Hippo signalling pathway that is an evolutionarily conserved pathway affect diver's pathology and physiology processes, including tissue repair, wound healing, tissue size and tissue regeneration. Epigenetic changes are post-translational modifications in DNA proteins and histone. Epigenetic changes including histone acetylation and deacetylation, miRNAs dysregulation, and aberrant DNA methylation, inflammatory genes actives abnormal in Hippo signaling pathway. Using some treatments including Histone deacetylases (HDACs), herbal composition, siRNAs and long non-Coding RNA (lncRNA) for suppress of cancer cells by targeting Hippo pathways, may open new view in cancer target therapy fields. The aim of this review study is first demonstrating the importance of Hippo signalling and its association with epigenetic changes in cancer and then to demonstrate progress in targeting Hippo signalling in cancer therapy.