Scabronine A, a novel diterpenoid having potent inductive activity of the nerve growth factor synthesis, isolated from the mushroom, Sarcodon scabrosus

Abstract A novel diterpenoid, scabronine A, having strong inductive activity of the nerve growth factor synthesis was isolated from the fruit body of the mushroom, Sarcodon scabrosus (Fr.) Karst. The stereostructure of scabronine A ( 1 ) was elucidated on the basis of the spectroscopic analysis of natural scabronine A and its derivatives.