An Antiparasitic Compound from the Medicines for Malaria Venture Pathogen Box Promotes Leishmania Tubulin Polymerization

Imran Ullah,Suraksha Gahalawat,Laela M. Booshehri,Hanspeter Niederstrasser,Shreoshi Majumdar,Christopher Leija,James M. Bradford,Bin Hu,Joseph M. Ready,Dawn M. Wetzel

An Antiparasitic Compound from the Medicines for Malaria Venture Pathogen Box Promotes Leishmania Tubulin Polymerization

2020

Imran Ullah
Suraksha Gahalawat
Laela M. Booshehri
Hanspeter Niederstrasser
Shreoshi Majumdar
Christopher Leija
James M. Bradford
Bin Hu
Joseph M. Ready
Dawn M. Wetzel

The few frontline antileishmanial drugs are poorly effective and toxic. To search for new drugs for this neglected tropical disease, we tested the activity of compounds in the Medicines for Malaria...

Keywords:

Antiparasitic
Virology
Tropical disease
Malaria
Leishmania
Drug discovery
Pathogen
Parasite hosting
Tubulin
Biology

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