Study of stability of ketoconazole microcapsules

Objective: To study the stability of ketoconazole and search a method to improve its stability. Methods: The accelerated stable test and long - term stable test were made with ketoconazole microcapsules prepared by us. Then the content and surface properties of ketoconazole before and after encapsulated were studied. Results: In the conditions of high temperature, high humidity, strong light or long - term room temperature, little changes of physical and chemical properties of ketoconazole in the microcapsules were be found, whereas, both concentration and color of ketoconazole powder changed very much in the same conditions as above. Conclusion: The microencapsulation of ketoconazole can improve the stability of this drug.