Conjugation of 1-Aminoadamantanes and 5-Trifluoromethylhydantoins by 1,3-Dipolar Cycloaddition

A synthetic approach was proposed for combining pharmacophore scaffolds, namely, 1-aminoadamantanes and 5-trifluoromethylhydantoins by the copper-catalyzed 1,3-dipolar alkyne-azide cycloaddition reaction.