Activity of ethanol extract of purpleleaves (Graptophyllumpictum(Linn.)Griff.) onalloxan-induced diabetes mice

Diabetes mellitus is a common endocrine disorder characterized by hyperglycemia and one of the major causes of death. This study aims to determine the antidiabetic activity of ethanol extract of purple leaves (Graptophyllumpictum (Linn.) Griff.)in mice. In this study, the inductionalloxan dose of 168 mg/kgbw in male mice and divided into 5 treatment groups. Group 1 to 3 are given the extract orally each concentration 140, 210, and 280 mg/kgbw, group 4 was given glibenclamide a dose of 0.65 mg/kgbw and group 5 given Na.CMC solution of 1% w/v. The results obtained in the analysis by paired t-test and test-one-way ANOVA showed a significant decrease (p <0.05). Based on the results of this study concluded that the ethanol extract of purple leaves has an activities in reducing blood glucose levels and the most effective concentration was 210 mg / kgbw with a percent decrease of 70.4%.