Endogenous variation in estradiol in women affects the weighting of metric and categorical information in spatial location memory.

Abstract Recent work has suggested that sex differences may exist in the strategies or types of cues that are utilized by men and women to remember discrete spatial locations or routes through a visual environment. The current study investigated the effects of circulating estradiol levels in women on the relative weighting of categorical versus fine-grained ‘metric’ information in a test of short-term memory for spatial locations, either presented within a simple geometric surround (a circular enclosure) or within more visually complex landscape scenes. Patterns of displacement error in the point location estimates made by men and women were analyzed. Results confirmed a sex difference in the weighting of metric versus categorical cues. Relative to men, women's estimates of locations were more strongly biased toward the center of the surrounding category (i.e., toward the category ‘prototype’). Furthermore, objective measures of estradiol via saliva collected at the time of memory testing showed that, among naturally-cycling women, estradiol concentrations correlated in a positive, graded, fashion with the degree of emphasis that women placed on categorical information when estimating point locations. No associations were found for progesterone. These findings are consistent with a wider body of research showing that biological sex and reproductive hormone levels, including 17β-estradiol, can subtly influence performance on certain spatial tasks. This is the first study to show that circulating estradiol levels may influence the relative emphasis placed on categorical versus metric cues when remembering simple point locations.