Twin pregnancies after assisted reproductive technologies: the role of maternal age on pregnancy outcome

Abstract Objectives Our aim was to investigate whether advanced maternal age (≥40 years) still impairs the outcome of twin pregnancies after assisted reproductive techniques (ART). Study design The retrospective observational study evaluated 430 nulliparous dichorionic diamniotic twin pregnancies conceived with ART. The population was divided into women Results Gestational diabetes mellitus and gestational hypertension/preeclampsia were significantly more frequent in nulliparous twin pregnancies after ART ≥40 years compared to p  = 0.021 and p p  = 0.104). However, Group A showed higher rate of spontaneous preterm birth (SPB) p  = 0.023 and p  = 0.001, respectively). For delivery p  = 0.002). A higher incidence of PB was observed in Group B after heterologous treatment ( p Conclusions Our data indicate that nulliparous twin pregnancies conceived with ART in mothers ≥40 years old did not show significantly higher incidence of PB, even if an increased rate of iatrogenic PB