Abstract 18082: Poor Fontan Geometry, Hemodynamics, and Computational Fluid Dynamics Are Associated With Worse Quality of Life

Introduction: Fontan palliation results in favorable short-term outcomes but limited exercise tolerance and poor quality of life (QOL) years after completion. Vessel narrowing and power loss in Fontan survivors results in worse exercise tolerance. Hypothesis: Poor Fontan geometry, computational fluid dynamics (CFD), and ventricular function is associated with worse QOL. Methods: Fontan survivor >12 yrs from a single center who completed a cardiac magnetic resonance (CMR) and supine metabolic exercise stress test were included. CMR-derived variables included Fontan geometry, hemodynamics and ventricular function. Geometry was analyzed by vascular modeling toolkit. CFD simulations were performed to quantify normalized power loss at rest and anaerobic threshold, pressure drop and resistance across the Fontan. QOL was assessed by subject completion of the Pediatric Quality of Life Inventory (PedsQL) at the time of CMR or after a baseline CMR [Follow-up (FU) QOL]. Comparisons were made between CMR and CFD para...