Sex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice.

We illustrate sex dimorphisms in crossbridge kinetics where male hypertrophic cardiomyopathy hearts displayed an increased while female hypertrophic cardiomyopathy hearts displayed a decreased tension cost. In addition, we have found sex- and mutation-dependent differences in cardiac remodeling at the morphometric, histological, and cellular level.