Применение кишечных органоидов для персонализированной диагностики и терапии муковисцидоза

In the last 10 years the biological three-dimensional model systems for long-term in vitro culture, similar in structure, performed functions and cellular composition with different organs - the organoids were developed. Currently, organoids represent a unique model for personalized treatment scheme selection, studying of fundamental processes and genetic, oncological and infectional diseases. Intestinal organoid cultures are utilized as a sensitive screening platform for estimation of CFTR channel functional properties, cystic fibrosis diagnostics and prescription of personalized treatment regimen for this disease.