Oxidative Stress and Amyloid-Beta Pathology in Normal Individuals with A Maternal History of

Results: Groups were comparable for demographic and neuropsychological measures. The MH subjects showed higher IsoP and reduced A42/40 CSF levels compared with NH and with PH (p values .05), whereas no differences were found between NH and PH. No group differenceswerefoundforP-Tau231andT-Tau.TheIsoPandA42/40levelswerecorrelatedonlywithintheMHgroup(R 2 .32,p.005)and discriminated MH from the other subjects with 70% accuracy (relative risk 3.7%, 95% confidence interval 1.6‐9.7, p .001). Results remained significant controlling for age, gender, education, and apolipoprotein E genotype. Conclusions: Adult children of LOAD-affected mothers express a pathobiological phenotype characterized by A-associated oxidative stress consistent with AD, which might reflect increased risk for developing the disease.