IMPROVED METHOD FOR THE SYNTHESIS OF 1-VINYLINDOLE
2013
A highly efficient method has been developed for the synthesis of 1-vinylindole based on the vinylation of indole by acetylene at atmospheric pressure using the superbase KOH–DMSO catalytic system. The method allows the preparation of the 1-vinylindole in 94% yield with a purity of 99% (after a single distillation of the crude product).
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