Relationship between urinary podocyte excretion and IgA nephropathy.

Objective The aim of this study was to investigate the relationship between urinary podocyte excretion and severity of renal pathological injury in IgA nephropathy.Methods We selected 36 cases of patients with IgA nephropathy and divided into 4 groups according to Lee histopathological classification.Urinary podocytes were examined by immunocytochemistry methods and maked by mouse anti-human podocalyxin monoclonal antibody.We counted the podocytes and examined the laboratory index.We analyzed relationship between urinary podocytes,clinical laboratory index and renal pathological injury of IgA nephropathy.Results Urinary protein quantitation,cholesterol,urea nitrogen and serum creatinine in group 4 of IgA nephropathy were apparently more than that in group 1,and plasma albumin were apparently lower.Urinary protein quantitation and urea nitrogen were statistically difference between group 1 and group 3.However,only urea nitrogen in group 2 was statistically different from that in group 1(P 0.05).The number of podocytes in the urine of patients with in group 4 of IgA nephropathy were apparently more than that in group 1 and group 2(P 0.05).There was obvious correlation of urinary podocyte with Lee histopathological classification of IgA nephropathy(r=0.432,P=0.01).Conclusion The mean level of podocytes in urinary excretion increased with pathological changes of IgA nephropathy aggravated,and there was obviousiy relative.