Relationship between CD14 C-260T promoter polymorphism and serum C-reactive protein levels in patients with coronary heart disease

Objective To investigate the relationship of serum levels of high sensitivity C-reactive protein(Hs-CRP) with CD14 C-260T promoter polymorphism in patients with coronary heart disease (CHD).Methods Serum levels of Hs-CRP were determined in 240 patients with coronary heart disease. C-260T promoter polymorphism of the CD14 gene was screened by PCR-RELP assay. Results The genotype distribution of the C-260T polymorphism of the CD14 gene was as follows: TT in 106 of 240 patients (44.2%),TC in 82 of 240 patients(34.1%) and CC in 52 of 240 patients(21.7%). Patients with TT subtype had increased Hs-CRP levels compared with carriers of the C allele (P0.05) . A higher percentage of T allele homozygotes had Hs-CRP levels 3 mg/L (P0.05). Conclusion This study indicated T allele homozygotes of CD14 gene may be an independent risk factor in systemic inflammation with stable CHD.