3H-imipramine binding in neuronal and glial fractions of horse striatum

The glial fraction prepared from horse striatum contained less than 20% of the specific high affinity 3H-imipramine binding sites found in the neuronal fraction prepared from the same tissue. The binding in the glial fraction was considered to result from minor cross-contamination of the two fractions. It is thus conclude that there is probably no specific 3H-imipramine binding in glial cells.