The ADR-01 dialysis device with dialyzate regeneration: Design and results of preliminary testing

1. The ADR-01 dialysis device with the DIP-02-02 dialyzer (1 m2 of “kuprofan” membrane, 500 ml/min perfusate flow rate) under recirculation mode and electrochemical regeneration of 3 liters of perfusate during 3.5–4 h operation provides reduction of concentration of urea and creatinine by 40–60% with the average flow rate of not less than 8 g/h. Such reduction of concentration corresponds to the efficiency of dialysis devices with dialyzate discharge of 100–120 liters per dialysis procedure. The 30–40-fold reduction of dialyzate volume eliminates the necessity for complex, bulky, expensive, and scarce auxiliary equipment for preparation of water and concentrate.