Synthesis of new pyrazoline derivatives and their cytotoxic and antiinflammatory screening

Six new derivatives of pyrazoline incorporated imidazo(1,2-a)pyridines 6(a-f) were synthesized and evaluated against anti inflammatory and invitro anti cancer activities. Claisen- Schmidt condensation of 2-aryl imidazo( 1,2-a) carbaldehydes (4a&4b) with substituted acetophenones gave 2-aryl imidazo pyridinyl chalcones 5(a-f). Cyclization of 5(a-f) with hydrazine hydrate afforded 2-(4- substituted phenyl)-3-(3-(4- substituted phenyl)4,5-dihydro-1Hpyrazol- 5-yl)imidazo[1,2-a]pyridines 6(a-f) in good yields. The structures of the synthesized compounds were confirmed on the basis of physical and spectral data. In MTT assay,some of the compounds have shown superior activity against MCF-7 and Hela cell lines and moderate activity aganist DU-147 cell lines. In anti-inflammmatory screening, 6e exhibited significant activity while the other compounds were moderately active.