Integrated Analysis of a Noncoding RNA-Associated Competing Endogenous RNA Network in Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Dysregulation of both coding and long noncoding RNAs (lncRNAs) plays crucial role in the pathogenesis and development of the disease. In this study, we identified a profile of dysregulated RNAs using datasets from a public database. By incorporating all interactions between different RNAs, a competing endogenous RNA network was established to further illustrate the regulatory roles of noncoding miRNAs and lncRNAs. Moreover, a functional analysis showed that NAFLD is more closely associated with certain biological processes and pathways. Altogether, these results provide a helpful perspective on NAFLD and may assist future diagnosis and treatment of the disease.