Effects of Uremic Compounds on Cultured Myocytes: a Model for Uremic Myocardiopathy

Respiration is a central factor of metabolism in almost all tissues; thus, all pharmacological effects also concern the energy metabolism in a direct or an indirect manner. A system which allows determination of oxygen consumption and simultaneously application of the methods of light microscopy is therefore of general pharmacological interest, irrespective of the cell type under investigation. We present the application of such a test system to the study of myocardial cell responses after exposition to uremic compounds.