IMPACT OF FENOFIBRATE ON HEART RATE VARIABILITY AND VESSEL WALL STATE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

.Rigidity increase (increase of pulse wave transmission velocity) and elasticity decrease (increase of augmentation and rigidity indices) were determined, they were more prominent in patients with type 2 DM and obesity. We found out that all examined patients had autonomic dysfunction with the prevalence of sympathicotonia. Signifi cant correlation relationships were determined between parameters of autonomic regulation and rigid-elastic properties of vessels in patients with type 2 DM and obesity. It was determined, that in addition to its lipid-lowering effect, micronized form of fenofi brate also has pleiotropic corrective impact on disturbances of HRV and rigid-elastic properties of the vessel wall in patients with type 2 DM and obesity.