Integrated paper-based electroanalytical devices for determination of dopamine extracted from striatum of rat

Abstract A disposable, simple and low cost paper-based electrochemical device was applied for sensitive detection of dopamine. The double sided conductive carbon tape supported by ITO glass was modified with multi-wall carbon nanotubes and Nafion followed by treatment with oxygen plasma before it was used as the working electrodes to detect dopamine. Nafion could not only improve selectivity for the detection of dopamine by stopping ascorbic acid from reaching the electrode surface but also enhance electrochemical signals of dopamine. In addition, the effective area of the carbon tape electrode could remarkably influence the signal-noise ratio and reproducibility. Under optimized experimental conditions, the linear range of dopamine was measured to be from 10 nM to 1 μM. The integrated paper-based electroanalytical devices with the advantage of low sample volume could be applied for determination of dopamine extracted from the striatum of rat.