The Effect of a Serine Proteinase Inhibitor on DIC in Septic Abortion

A 21-year-old woman developed septic shock complicated by acute renal insufficiency after D & C to terminate early pregnancy. Although immediate and aggressive treatment improved the profound cardiovascular collapse, DIC became manifest. Gabexate mesilate, a serine proteinase inhibitor, was substituted for heparin and was beneficial in controlling the coagulopathy. In this case study, the efficacy of gabexate mesilate on DIC as well as the management and treatment of septic abortion are discussed.