Serum Albumin and Its Relationship with Glutathione Levels in Patients with Brain Tumor

Present study was carried out to compare the levels of serum albumin and glutathione in patients’ with brain tumor and healthy controls and to know the relationship between glutathione and serum albumin.The study was carried out in 30 patients with brain tumor and 30 healthy age matched controls. Glutathione levels were measured pectrophotometrically using Beutler’s method. Serum albumin and total protein were estimated using automated analyzer and serum globulin was calculated by subtracting albumin from total protein.There was significant decrease in levels of serum albumin, globulin and glutathione (p<0.001) in brain tumor patients compared to healthy controls. On applying Pearson’s correlation serum albumin levels correlated positively with glutathione (p<0.01, r = 0.777).Decreased albumin levels reduce the available protein bound thiols, along with decrease in glutathione levels which may further enhance the oxidative stress in patients with brain tumor. Keywords: Glutathione, Albumin, Oxidative stress, Brain tumor